We are interested in achieving a multiscale understanding of the molecular organization of living systems—specifically, how biomolecules are localized to distinct cellular compartments and how changes in signaling or cell state influence their organization within and between cells. To address these questions, we develop chemical and biophysical tools to probe, manipulate, and reprogram the spatial organization of proteins, RNAs, and other biomolecules in mammalian systems. We leverage these tools both to gain insight into fundamental biology and to overcome key challenges in the development of RNA‑based, protein-based, and cell‑based therapeutic systems. Through this approach, the lab has made important contributions to chemical biology, single molecule imaging, synthetic mechanobiology, and Notch signaling.

​

​​